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Aux Г‰tats-Unis, le modafinil est approuvГ© pour le traitement de la somnolence excessive associГ©e Г la narcolepsie et des troubles du sommeil liГ©s au travail postГ©, ainsi que des troubles de l'Г©veil associГ©s au travail postГ©. Le modafinil est un mГ©dicament dГ©livrГ© uniquement sur ordonnance, bien que certains auteurs aient soutenu qu'il pouvait ГЄtre obtenu hors AMM avec la bonne ordonnance. C'est un stimulant utilisГ© pour traiter la narcolepsie. On ne sait pas si l'utilisation pendant la grossesse est sans danger. Le modafinil est gГ©nГ©ralement bien tolГ©rГ©, avec des effets secondaires possibles, notamment des maux de tГЄte, des troubles du sommeil et des nausГ©es. De plus, les interactions possibles avec les hormones, les supplГ©ments nutritionnels et les produits Г base de plantes ne sont pas non plus claires. Les comprimГ©s sont blancs, oblongs, brillants ou translucides et peuvent ГЄtre imprimГ©s sur le comprimГ©. Le modafinil agit en diminuant la latence d'endormissement, en augmentant la vigilance et en rГ©duisant la somnolence matinale. MalgrГ© les effets pharmacologiques similaires sur le corps, le modafinil et l'armodafinil sont chimiquement diffГ©rents. Le modafinil, Г©galement connu sous le nom de Provigil, Modvigil et le nom commercial Armodafinil, est un mГ©dicament sur ordonnance, en particulier un stimulant du systГЁme nerveux central (SNC). Il y avait 248 personnes qui ont pris le mГ©dicament et ont eu des rГ©actions graves. Le modafinil ne remplace pas le sommeil et ne doit pas ГЄtre pris sans ajuster les habitudes de sommeil. On pense que le mГ©canisme d'action est dГ» Г l'activation des rГ©cepteurs de la dopamine dans le cerveau. Provigil En Maroc La dose initiale recommandГ©e pour les adultes est de 100 mg et la dose maximale prise est de 400 mg. Le modafinil interagit avec la voie de la noradrГ©naline, moins efficacement que la dopamine, mais plus que les autres stimulants. Il est pris par la bouche. Modafinil est disponible dans une variГ©tГ© de mГ©dicaments et de dosages. Les injections de modafinil chez les rongeurs entraГ®nent une augmentation des niveaux de dopamine extracellulaire dans l'hippocampe. Malheureusement, la recherche n'a pas abouti Г des conclusions concluantes sur l'innocuitГ© et l'efficacitГ©. Un patient prenant 200 mg/jour a rapportГ© des bГ©nГ©fices significatifs. Ces antagonistes des rГ©cepteurs A1 comprennent Г©galement des antagonistes non sГ©lectifs du rГ©cepteur A1 de l'adГ©nosine (voir Г‰thoxylates d'alxonylphГ©nol, brassinostГ©roГЇdes et piceatannol), entre autres. Le modafinil a Г©tГ© dГ©couvert en 1971 par des scientifiques de l'universitГ© de Reims. Le modafinil peut induire des sentiments d'euphorie et des sensations d'Г©nergie. On pense que le modafinil agit en imitant certains neurotransmetteurs.
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C'est un nom commercial pour deux prГ©parations pharmaceutiques de modafinil : RimГ©tropine et Nuvigile. L'effet de cette action est de produire une augmentation globale des niveaux de noradrГ©naline et de dopamine dans le cerveau et une augmentation de leurs niveaux dans la circulation sanguine, qui agit pour stimuler de nombreuses parties du corps. Le modafinil a Г©tГ© approuvГ© en France en 1994 pour la prise en charge de la somnolence diurne excessive due Г la narcolepsie. La FDA a approuvГ© l'utilisation du modafinil pour la narcolepsie en 1999. Il n'est pas recommandГ© chez les personnes souffrant d'arythmie, d'hypertension artГ©rielle importante ou d'hypertrophie ventriculaire gauche. Comme pour de nombreux mГ©dicaments, l'administration une fois par jour est prГ©fГ©rable Г l'administration plusieurs fois par jour afin de rГ©duire les doses hors cible. Le modafinil agit en interfГ©rant avec ces transporteurs, et donc le modafinil augmente le nombre de transporteurs de dopamine dans la synapse. Le comprimГ© doit ГЄtre pris le matin sans autre nourriture ni boisson. Cependant, on a dit qu'il avait un mГ©canisme d'action similaire Г ces stimulants dans le sens oГ№ il peut vous faire sentir plus Г©veillГ© en augmentant le mГ©tabolisme et le flux sanguin dans votre cerveau. L'Г©tat d'Г©quilibre est atteint en 3 heures environ. Pour certaines personnes, il faut deux semaines pour que le mГ©dicament atteigne son effet maximal. Le modafinil est un stimulant faible et ne provoque gГ©nГ©ralement pas d'augmentation du rythme cardiaque ou de la pression artГ©rielle. Ses effets sont similaires Г ceux de l'amphГ©tamine, le modafinil fournissant les effets favorisant l'Г©veil de la substance, sans les effets rГ©parateurs de l'amphГ©tamine. Il diffГЁre du composГ© prГ©cГ©dent, l'armodafinil (2-[(2R,3S)-2,3-dihydroxy-2-(mГ©thylthio)Г©thyl]-5-mГ©thyl-1-[(1H-tГ©trazol-5-yl)mГ©thyl] -1H-tГ©trazole-4-acide carboxylique (2S)-2,3,4-trihydroxy-6-mГ©thyl-3,7-dioxabicyclo[3. Une Г©tude publiГ©e en 1999 a rГ©vГ©lГ© que lorsque 100 mg de modafinil Г©taient pris au coucher, environ 35 % des personnes prenant le mГ©dicament montraient une amГ©lioration significative de leur capacitГ© Г rester Г©veillГ©es pendant qu'elles travaillaient, un effet comparable Г celui de 100 mg d'amphГ©tamine. Acheter Modafinil En Luxembourg Les deux isomГЁres du modafinil sont ensuite convertis en N-desmГ©thyl modafinil puis en mГ©latonine par l'enzyme cytochrome P450 1A2 (CYP1A2). Il n'y a actuellement pas suffisamment de donnГ©es pour dГ©terminer si l'utilisation du modafinil pendant la grossesse est sans danger. L'Г©nantiomГЁre d est un inhibiteur plus puissant du transporteur d'adГ©nosine que l'Г©nantiomГЁre l-thrГ©o. En augmentant les niveaux de norГ©pinГ©phrine, le modafinil agit comme un agoniste alpha-1 adrГ©nergique, provoquant la libГ©ration de plus de dopamine dans le cortex prГ©frontal. Le modafinil est le mГ©tabolite actif du mГ©dicament Armodafinil, qui fait partie de la mГЄme classe de mГ©dicaments et se mГ©tabolise en modafinil dans le foie. La plupart des Г©tudes rapportent que 200 mg est la dose efficace. On l'appelle souvent le modalert, modave ou Wake-Up. Son profil pharmacodynamique est diffГ©rent de celui du sulfate de modafinil : comme le modafinil lui-mГЄme, le mГ©tabolite du modafinil est mГ©tabolisГ© par l'enzyme CYP1A2, alors que le sulfate de modafinil ne l'est pas. De nombreux utilisateurs Г©prouvent des sensations de somnolence aprГЁs l'administration, et un petit nombre de sujets ont signalГ© des insomnies. Les femmes peuvent avoir un taux de mГ©tabolisme plus Г©levГ© et donc une demi-vie plus longue du modafinil par rapport aux hommes. Le modafinil est mГ©tabolisГ© dans le foie et est lentement absorbГ©.
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